What is Bextra?
Bextra (Valdecoxib) is similar to Celebrex (Celecoxib) in the respect that it is a prescription COX-2 selective inhibitor nonsteroidal anti-inflammatory drug (NSAID) used for the relief of pain associated with osteoarthritis (OA), rheumatoid arthritis (RA) and menstrual cramps (primary dysmenorrhea). Bextra was manufactured by Pharmacia Corporation/Pfizer, Inc., and it was approved for these purposes by the Food and Drug Administration (FDA) on November 16, 2001. The marketing of Bextra started in March 2002.
Bextra, similar to Celebrex, works by inhibiting the COX-2 form of the COX enzyme to block production of prostaglandins. Prostaglandins are hormone-like substances that contribute to the symptoms of pain, fever and inflammation.
Bextra tablets for oral administration contain either 10 mg or 20 mg of the active ingredient, valdecoxib. Inactive ingredients include lactose monohydrate, microcrystalline cellulose, pregelatinized starch, croscarmellose sodium, magnesium stearate, hydroxypropyl methylcellulose, polyethylene glycol, polysorbate 80, and titanium dioxide.
Bextra, similar to Celebrex, works by inhibiting the COX-2 form of the COX enzyme to block production of prostaglandins. Prostaglandins are hormone-like substances that contribute to the symptoms of pain, fever and inflammation.
Bextra tablets for oral administration contain either 10 mg or 20 mg of the active ingredient, valdecoxib. Inactive ingredients include lactose monohydrate, microcrystalline cellulose, pregelatinized starch, croscarmellose sodium, magnesium stearate, hydroxypropyl methylcellulose, polyethylene glycol, polysorbate 80, and titanium dioxide.
Other Tequin FAQs
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Q:
What is the COX enzyme?
A: The cyclooxygenase (COX) enzyme has two forms: COX-1 and COX-2. COX-1 is found in a lot of cells all the time, notably the lining of the stomach where it regulates … More -
Q:
What are NSAIDs?
A: NSAIDs are a large group of drugs that have pain-relieving (analgesic) and fever-reducing (antipyretic) effects, as well as the effect of reducing inflammation when … More -
Q:
Is Bextra right for me?
A: You should not take Bextra if you: • Had asthma, hives or allergic reactions after taking aspirin or other NSAIDs (nonsteroidal anti-inflammatory drugs) or … More -
Q:
What should I tell my health care provider?
A: Tell your health care provider if you: • have heart problems or high blood pressure; • have liver or kidney problems; • have or had … More -
Q:
What is the problem with Bextra?
A: Preliminary studies have indicated that Bextra (valdecoxib), an arthritis drug manufactured by Pfizer, Inc., could potentially be one of the leading causes of Stevens … More -
Q:
Did the Food and Drug Administration (FDA) know about these allergic reactions?
A: Yes. The FDA announced on November 15, 2002, that it had received about 20 reports of serious reactions, including skin diseases [Stevens Johnson Syndrome (SJS), … More -
Q:
What is Stevens Johnson Syndrome?
A: Stevens Johnson Syndrome (SJS) is an immune-complex-mediated hypersensitivity disorder that may be caused by a reaction to drugs (including Bextra), viral infections, … More -
Q:
What is toxic epidermal necrolysis?
A: Toxic epidermal necrolysis (a form of SJS) is a life-threatening skin disorder characterized by blistering of the mucous membranes (similar to Stevens Johnson … More -
Q:
What is exfoliative dermatitis?
A: Exfoliative dermatitis, also known as erythroderma, is an uncommon but serious skin disorder. Generalized exfoliative dermatitis is a severe inflammation of the … More -
Q:
What is erythema multiforme?
A: Erythema multiforme (EM) is a serious inflammatory skin eruption (rash) caused by allergic reactions to many different things, including prescription and … More