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I had a prescription for Vioxx, and now that Vioxx is off the market, what questions should I ask my doctor in choosing a different COX-2 inhibitor?

There are four questions that should be considered when considering a COX-2 inhibitor NSAID:

1. Is the COX-2 inhibitor agent selective? (An agent must be more than 100-fold more COX-2 selective than COX-1 to meet this criteria.)

2. Does the COX-2 inhibitor agent have a sparing effect for stomach ulcers and other gastrointestinal bleeding and complications?

3. Does the COX-2 inhibitor agent spare platelet function? (This is particularly important for those at risk for heat attacks, strokes or other cardiovascular condition caused by blood clots.)

4. Is the COX-2 inhibitor agent effective clinically?

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