What is the COX enzyme?

The cyclooxygenase (COX) enzyme has two forms: COX-1 and COX-2. COX-1 is found in a lot of cells all the time, notably the lining of the stomach where it regulates acid production. COX-2 is not present in most cells normally, only appearing when things are going wrong. As a result, COX-2 was thought to be responsible for the bad effects of the COX enzyme-pain and inflammation. Vioxx was developed based on this belief that COX-2 was responsible for the bad effects of the COX enzyme and to reduce or even eliminate the gastrointestinal risks involved with the non-selective (traditional) NSAIDs like Aspirin (acetylsalicylic acid, ASA), Ibuprofen, Nabumetone and Naproxen, that inhibit both COX-1 and COX-2 enzymes. However, COX-2 serves other purposes besides its role in inflammation. Among the purposes the COX-2 enzyme serves is that it plays a major role in controlling the cardiovascular system-stopping platelets from forming blood clots (thrombi - plural form of thrombus) in the heart, and preventing damage to vessels. It also serves other functions that are beyond the scope of this FAQ section to explain.

The information on this page is meant to provide a general overview of the law. The laws in your state and/or city may deviate significantly from those described here. If you have specific questions related to your situation you should speak with a local attorney.

Additional Bextra Articles

Search LawInfo's Bextra Resources