Is it true that bladder cancer has been associated with using Actos?

Yes.  On June 15, 2011 the FDA released a safety announcement (http://www.fda.gov/Drugs/DrugSafety/ucm259150.htm) informing the public that using Actos for more than one year may increase the risk of bladder cancer.  They further noted that individuals who receive treatment for bladder cancer should not take Actos.
 

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